Endocrine Abstracts

We have recently observed that the peroxisome proliferator receptor α was expressed by normal and tumoural pituitary tissues, in particular by somatotrophs. To elucidate its function, we have studied the effects of fenofibrate on cell proliferation and GH secretion in GH3 cells.Material and methods: GH3 cells were grown in Ham’s F10 and treated for 24, 48 and 72 h by different concentrations of fenofibrate (12.5–50 &#...

Introduction: Pituitary surgery is currently considered the preferred treatment for Cushing’s disease (CD) and achieves remission in 55–85% of patients. Cortisol falls quickly after surgery, so that early post-operative cortisol level has been used as predictor of remission. There’s no agreement about optimal timing for cortisol measurement, with wide variability between centres.Objective: To assess the value of early post-operative serum ...

Introduction: Cushing’s disease (CD) is characterised by pathologic hypercortisolism caused by an ACTH-secreting pituitary adenoma. The primary modality for definitive treatment is pituitary surgery. The rarity of CD has made it difficult to establish reliable predictive factors of outcomes.Aim: Assessment of clinical, hormonal, radiological, surgical and histological findings as predictors of remission and relapse of CD.Metho...

Hypopituitarism as deficiency of one or more anterior pituitary hormones, in adults can be consequence of acquired or genetic causes. Only few published studies investigated population-based aetiology of hypopituitarism. In the last 10 years new risks for hypopituitarism have been recognised (traumatic brain injury-TBI, subarachnoid haemorrhage, cranial irradiation).Aim: To present our experiences in the aetiology of hypopituitarism based on data collect...

Background: Pituitary adenoma (PA) is an under-investigated pathology in the elderly.Objective: To review our case records of patients >70 years with PA, in order to evaluate presentation symptoms, hormonal results, and pituitary morphology.Patients: 48 patients aged 70 years or older (21 females/27 males) were identified from the group of 610 patients with PA (7.9%) diagnosed at Neuroendocrine Unit, Clinic for Endocrinology, B...

Introduction: Anaplastic thyroid cancer is a devastating disease with median survival between 1.2 and 10 months. The disease accounts for as little as 0.9–1.6% of total thyroid cancer cases, but may account for up to half of all thyroid cancer mortality. The aim of our study is to evaluate the prognostic factors and outcomes of patients diagnosed with anaplastic thyroid cancer in Ireland and review emerging treatments for this disease.Methods and de...

Introduction: Medullary thyroid cancer arises from the calcitonin-secreting parafollicular C cells and consists of a spectrum of disease that ranges from extremely indolent tumours, where patients may survive for many years with a large tumor burden, to aggressive types associated with a high mortality rate. The objective of our study is to evaluate the prognostic factors and outcomes of patients diagnosed with medullary thyroid cancer in a homogenous population, and to examin...

Introduction: The increased incidence of thyroid cancer is driven mainly by a large increase in papillary thyroid cancer (PTC). The number of patients that succumb to the disease has remained stable. The aim of our study is to analyze the incidence and mortality of thyroid cancer in Ireland.Methods and design: A retrospective analysis of the National Cancer Registry was undertaken, between 1st of January 1998 and the 31st December 2007. The Kaplan–M...

Introduction: Autoimmune thyroid diseases, including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), are complex diseases combining genetic susceptibility and environmental encounters leading to the breakdown of immune tolerance. The relationship between thyroid cancer (TC) and HT has been proven (Guarino et al. 2010), and the antibody specific association has been demonstrated (Azizi et al. 2014). Overexpression of claudin-1 appears to be an...

Introduction: We wanted to analyse the descriptive variables of a series of 1567 thyroidectomy patients between 2010 and 2013 and its association with malignancy in our series.Material and methods: Retrospective, multicentre study done by review of the medical records of 1567 patients who became thyroidectomy between 2010 and 2013 in eight sanitary areas. This is an analysis of clinical and demographic variables.Results: The percen...